Abstract
Osteochondral defects (OCDs) present a significant challenge in orthopedics, as they involve simultaneous damage to cartilage and underlying bone. Current clinical options remain limited, underscoring the need for innovative regenerative solutions. This work introduces a biphasic scaffold, designed using triply periodic minimal surface (TPMS) gyroid architectures, as a novel strategy for osteochondral repair. The scaffolds were fabricated from polylactic acid (PLA) using fused deposition modeling (FDM), enabling precise replication of complex anatomical interfaces. Preliminary investigation demonstrates that the biphasic gyroid scaffolds exhibit enhanced mechanical integrity and biodegradability. These properties suggest great potential for improving osteochondral regeneration compared to conventional scaffold designs. By integrating advanced additive manufacturing techniques with biomimetic design, this study indicates a pathway toward next-generation 3D scaffolds for orthopedic tissue engineering, with a specific focus on bone and cartilage regeneration.
Keywords: biphasic scaffold; osteochondral defect; gyroid scaffold; fused deposition modelling; tissue engineering
Biography
Dr. Md Enamul Hoque is a Professor of Biomedical Engineering at the Military Institute of Science and Technology (MIST), Dhaka, Bangladesh. Formerly Head of Biomedical Engineering at King Faisal University, Saudi Arabia, and Founding Head of Bioengineering at the University of Nottingham Malaysia, he earned his PhD from the National University of Singapore and PGCHE from the University of Nottingham, UK. A Chartered Engineer and Fellow of IMechE and HEA (UK), he has published extensively (134 journal papers, 14 books, 106 book chapters). His publications have attracted around 6800 citations with 39 h-index and 110 i-10 index (https://scholar.google.com/citations?user=aRvzzrEAAAAJ&hl=en). He has and received multiple awards. He is now ranked among the world’s top 2% scientists. https://topresearcherslist.com/Home/Profile/893329
