Abstract
Solubilization strategies, including mechanochemical techniques such as: electrospinning, hot melt extrusion, and the use of supercritical carbon dioxide were employed to prepare modified cannabinoid delivery systems. Due to the poor solubility of cannabinoids substantially limits their therapeutic potential in topical formulations such as 3D-printed hydrogels, which represent a highly suitable delivery platform for many types of wounds, including burns, chronic ulcers, diabetic foot lesions or pressure sores. Therefore, this study focused on improving the solubility of cannabinoids to enable their effective incorporation into semi-solid systems intended for personalized 3D-printed wound-healing applications, ensuring enhanced release and more consistent therapeutic performance. These mechanochemcial techniques are recognized as green processing methods due to their low solvent requirements, reduced environmental impact, and suitability for sustainable pharmaceutical manufacturing. The amorphization of cannabinoids in these formulations was confirmed using XRPD, FT-IR, and DSC analyses, providing clear evidence of structural transformation. The resulting solubilized systems demonstrated enhanced dissolution properties, supporting their improved compatibility with hydrogel matrices and facilitating uniform distribution within the final formulations. These findings indicate that amorphous, solubilized forms of cannabinoids can be successfully incorporated into 3D-printable semi-solid formulations, paving the way for personalized wound-healing platforms enriched with therapeutic cannabinoids.
These results collectively demonstrate that solubilization of cannabinoids using supercritical carbon dioxide and electrospinning provides a robust and environmentally friendly foundation for the development of advanced, next-generation wound dressings, ultimately enabling their incorporation into fully personalized formulations produced through 3D printing.
Biography
Professor Judyta Cielecka-Piontek, a graduate of Adam Mickiewicz University and the Poznan University of Medical Sciences (PUMS), leads the Department of Pharmacognosy and Biomaterials at PUMS. Her research focuses on mechanosynthesis, improving solubility of active compounds, and developing innovative drug-delivery systems, including personalized 3D-printed materials for wound healing. She has authored over 280 scientific papers and managed numerous basic and applied research projects. In 2024 and 2025, she was listed among the World’s Top 2% Scientists by Stanford University, and her research achievements have been repeatedly implemented in industry.
