Wen-Hsiung Li is a distinguished scientist known for his major contributions to evolutionary biology, genomics, and bioinformatics. He completed his early education in Taiwan, earning a B.E. in Civil Engineering from Chung-Yuang College of Science and Engineering in 1965 and an M.S. in Geophysics from National Central University in 1968, before moving to the United States to obtain a Ph.D. in Applied Mathematics from Brown University in 1972. His research interests span biotechnology, synthetic biology, molecular evolution, evolutionary genomics, and computational biology. Over his long and influential career, Li has held numerous prestigious academic positions. He currently serves as a Distinguished Research Fellow at the Biodiversity Research Center, Academia Sinica in Taiwan, and as the James D. Watson Professor Emeritus at the University of Chicago. He also holds joint and chair professorships at several leading Taiwanese universities, including National Taiwan University and National Tsing Hua University. Previously, he held important roles such as George Beadle Professor and Director of the Biodiversity Research Center at Academia Sinica, along with professorships at the University of Texas Health Science Center-Houston and research positions at the University of Wisconsin-Madison. Li’s achievements have been widely recognized with numerous honors, including election as an Academician of Academia Sinica, Fellow of the American Academy of Arts and Sciences, and Member of the U.S. National Academy of Sciences. He has received major awards such as the Balzan Prize for Genetics and Evolution, the Mendel Lecture and Medal, the Society for Molecular Biology and Evolution Lifetime Contribution Award, the Presidential Science Prize in Taiwan, and the Kimura Award. In addition to his research and teaching, Li has played a significant role in the scientific community through leadership and editorial work. He has served as president of several scientific societies, including the Society for Molecular Biology and Evolution and the Bioinformatics Society of Taiwan, and has contributed as editor or board member for many leading journals in genetics, evolution, and computational biology. His extensive professional service and lifelong dedication have made him one of the most influential figures in modern evolutionary and computational biology.