{"id":5223,"date":"2026-02-24T16:23:58","date_gmt":"2026-02-24T16:23:58","guid":{"rendered":"https:\/\/cognitionconferences.com\/virology\/?post_type=speaker&p=5223"},"modified":"2026-02-24T16:23:58","modified_gmt":"2026-02-24T16:23:58","slug":"jia-li","status":"publish","type":"speaker","link":"https:\/\/cognitionconferences.com\/virology\/speaker\/jia-li\/","title":{"rendered":"Jia Li"},"content":{"rendered":"

Abstract<\/strong><\/p>\n

Ribonucleoprotein complexes (RNPs), composed of viral genomic RNA encapsidated by nucleocapsid (NP) protein and associated with the viral polymerase, are the functional units for replication and transcription of negative-sense RNA viruses (NSVs). However, how RNP assembly is regulated remains poorly understood. Here, using the plant-infecting NSV Tomato spotted wilt virus as a model, we uncover a lipid-metabolism\u2013driven regulatory pathway linking host fatty acid synthase (FASN) activity, palmitoyltransferase, and viral protein palmitoylation to RNP assembly. The viral RNA-dependent RNA polymerase (L protein) recruits FASN and enhances its self-association, which is required for proviral activity. FASN-derived palmitate supports zDHHC14-mediated palmitoylation of NP at residue C194 in planta. Disruption of this modification selectively impairs NP-L interaction without affecting NP localization, oligomerization, or intracellular trafficking, resulting in defective RNP assembly and reduced viral replication. Together, our findings uncover a direct mechanistic link between host fatty acid synthesis and viral RNP formation, revealing an unexpected role for lipid metabolic enzymes in regulating negative-sense RNA virus replication.<\/p>\n","protected":false},"featured_media":5222,"template":"","meta":{"_acf_changed":false},"schedule":[],"speaker-category":[],"class_list":["post-5223","speaker","type-speaker","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"\nJia Li | Nanjing Agricultural University | China<\/title>\n<meta name=\"description\" content=\"Jia Li has completed his PhD at the age of 27 years from Nanjing Agricultural University. Over the following five years, he conducted collaborative research in structural biology at the Center for Excellence in Molecular Plant Sciences of the Chinese Academy of Sciences in Shanghai and later at the Institute of Biophysics, Chinese Academy of Sciences in Beijing. His current research integrates plant virology, biochemistry, and structural biology to determine the three-dimensional structures and functions of key protein complexes formed by plant viral proteins and their host factors. Through these multidisciplinary approaches, his work aims to elucidate the molecular mechanisms underlying plant virus pathogenicity and plant immune responses.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cognitionconferences.com\/virology\/speaker\/jia-li\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Jia Li | Nanjing Agricultural University | China\" \/>\n<meta property=\"og:description\" content=\"Jia Li has completed his PhD at the age of 27 years from Nanjing Agricultural University. Over the following five years, he conducted collaborative research in structural biology at the Center for Excellence in Molecular Plant Sciences of the Chinese Academy of Sciences in Shanghai and later at the Institute of Biophysics, Chinese Academy of Sciences in Beijing. His current research integrates plant virology, biochemistry, and structural biology to determine the three-dimensional structures and functions of key protein complexes formed by plant viral proteins and their host factors. Through these multidisciplinary approaches, his work aims to elucidate the molecular mechanisms underlying plant virus pathogenicity and plant immune responses.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cognitionconferences.com\/virology\/speaker\/jia-li\/\" \/>\n<meta property=\"og:site_name\" content=\"Cognition Conferences\" \/>\n<meta property=\"og:image\" content=\"https:\/\/cognitionconferences.com\/virology\/wp-content\/uploads\/2026\/02\/Dyar-Mudhafar-Salman-2.png\" \/>\n\t<meta property=\"og:image:width\" content=\"500\" \/>\n\t<meta property=\"og:image:height\" content=\"600\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/cognitionconferences.com\/virology\/speaker\/jia-li\/\",\"url\":\"https:\/\/cognitionconferences.com\/virology\/speaker\/jia-li\/\",\"name\":\"Jia Li | Nanjing Agricultural University | China\",\"isPartOf\":{\"@id\":\"https:\/\/cognitionconferences.com\/virology\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/cognitionconferences.com\/virology\/speaker\/jia-li\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/cognitionconferences.com\/virology\/speaker\/jia-li\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/cognitionconferences.com\/virology\/wp-content\/uploads\/2026\/02\/Dyar-Mudhafar-Salman-2.png\",\"datePublished\":\"2026-02-24T16:23:58+00:00\",\"description\":\"Jia Li has completed his PhD at the age of 27 years from Nanjing Agricultural University. Over the following five years, he conducted collaborative research in structural biology at the Center for Excellence in Molecular Plant Sciences of the Chinese Academy of Sciences in Shanghai and later at the Institute of Biophysics, Chinese Academy of Sciences in Beijing. His current research integrates plant virology, biochemistry, and structural biology to determine the three-dimensional structures and functions of key protein complexes formed by plant viral proteins and their host factors. Through these multidisciplinary approaches, his work aims to elucidate the molecular mechanisms underlying plant virus pathogenicity and plant immune responses.\",\"breadcrumb\":{\"@id\":\"https:\/\/cognitionconferences.com\/virology\/speaker\/jia-li\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/cognitionconferences.com\/virology\/speaker\/jia-li\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/cognitionconferences.com\/virology\/speaker\/jia-li\/#primaryimage\",\"url\":\"https:\/\/cognitionconferences.com\/virology\/wp-content\/uploads\/2026\/02\/Dyar-Mudhafar-Salman-2.png\",\"contentUrl\":\"https:\/\/cognitionconferences.com\/virology\/wp-content\/uploads\/2026\/02\/Dyar-Mudhafar-Salman-2.png\",\"width\":500,\"height\":600},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/cognitionconferences.com\/virology\/speaker\/jia-li\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/cognitionconferences.com\/virology\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Jia Li\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/cognitionconferences.com\/virology\/#website\",\"url\":\"https:\/\/cognitionconferences.com\/virology\/\",\"name\":\"Cognition Conferences\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/cognitionconferences.com\/virology\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Jia Li | Nanjing Agricultural University | China","description":"Jia Li has completed his PhD at the age of 27 years from Nanjing Agricultural University. Over the following five years, he conducted collaborative research in structural biology at the Center for Excellence in Molecular Plant Sciences of the Chinese Academy of Sciences in Shanghai and later at the Institute of Biophysics, Chinese Academy of Sciences in Beijing. His current research integrates plant virology, biochemistry, and structural biology to determine the three-dimensional structures and functions of key protein complexes formed by plant viral proteins and their host factors. Through these multidisciplinary approaches, his work aims to elucidate the molecular mechanisms underlying plant virus pathogenicity and plant immune responses.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/cognitionconferences.com\/virology\/speaker\/jia-li\/","og_locale":"en_US","og_type":"article","og_title":"Jia Li | Nanjing Agricultural University | China","og_description":"Jia Li has completed his PhD at the age of 27 years from Nanjing Agricultural University. Over the following five years, he conducted collaborative research in structural biology at the Center for Excellence in Molecular Plant Sciences of the Chinese Academy of Sciences in Shanghai and later at the Institute of Biophysics, Chinese Academy of Sciences in Beijing. His current research integrates plant virology, biochemistry, and structural biology to determine the three-dimensional structures and functions of key protein complexes formed by plant viral proteins and their host factors. Through these multidisciplinary approaches, his work aims to elucidate the molecular mechanisms underlying plant virus pathogenicity and plant immune responses.","og_url":"https:\/\/cognitionconferences.com\/virology\/speaker\/jia-li\/","og_site_name":"Cognition Conferences","og_image":[{"width":500,"height":600,"url":"https:\/\/cognitionconferences.com\/virology\/wp-content\/uploads\/2026\/02\/Dyar-Mudhafar-Salman-2.png","type":"image\/png"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/cognitionconferences.com\/virology\/speaker\/jia-li\/","url":"https:\/\/cognitionconferences.com\/virology\/speaker\/jia-li\/","name":"Jia Li | Nanjing Agricultural University | China","isPartOf":{"@id":"https:\/\/cognitionconferences.com\/virology\/#website"},"primaryImageOfPage":{"@id":"https:\/\/cognitionconferences.com\/virology\/speaker\/jia-li\/#primaryimage"},"image":{"@id":"https:\/\/cognitionconferences.com\/virology\/speaker\/jia-li\/#primaryimage"},"thumbnailUrl":"https:\/\/cognitionconferences.com\/virology\/wp-content\/uploads\/2026\/02\/Dyar-Mudhafar-Salman-2.png","datePublished":"2026-02-24T16:23:58+00:00","description":"Jia Li has completed his PhD at the age of 27 years from Nanjing Agricultural University. Over the following five years, he conducted collaborative research in structural biology at the Center for Excellence in Molecular Plant Sciences of the Chinese Academy of Sciences in Shanghai and later at the Institute of Biophysics, Chinese Academy of Sciences in Beijing. His current research integrates plant virology, biochemistry, and structural biology to determine the three-dimensional structures and functions of key protein complexes formed by plant viral proteins and their host factors. Through these multidisciplinary approaches, his work aims to elucidate the molecular mechanisms underlying plant virus pathogenicity and plant immune responses.","breadcrumb":{"@id":"https:\/\/cognitionconferences.com\/virology\/speaker\/jia-li\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/cognitionconferences.com\/virology\/speaker\/jia-li\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/cognitionconferences.com\/virology\/speaker\/jia-li\/#primaryimage","url":"https:\/\/cognitionconferences.com\/virology\/wp-content\/uploads\/2026\/02\/Dyar-Mudhafar-Salman-2.png","contentUrl":"https:\/\/cognitionconferences.com\/virology\/wp-content\/uploads\/2026\/02\/Dyar-Mudhafar-Salman-2.png","width":500,"height":600},{"@type":"BreadcrumbList","@id":"https:\/\/cognitionconferences.com\/virology\/speaker\/jia-li\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/cognitionconferences.com\/virology\/"},{"@type":"ListItem","position":2,"name":"Jia Li"}]},{"@type":"WebSite","@id":"https:\/\/cognitionconferences.com\/virology\/#website","url":"https:\/\/cognitionconferences.com\/virology\/","name":"Cognition Conferences","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/cognitionconferences.com\/virology\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/cognitionconferences.com\/virology\/wp-json\/wp\/v2\/speaker\/5223","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cognitionconferences.com\/virology\/wp-json\/wp\/v2\/speaker"}],"about":[{"href":"https:\/\/cognitionconferences.com\/virology\/wp-json\/wp\/v2\/types\/speaker"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cognitionconferences.com\/virology\/wp-json\/wp\/v2\/media\/5222"}],"wp:attachment":[{"href":"https:\/\/cognitionconferences.com\/virology\/wp-json\/wp\/v2\/media?parent=5223"}],"wp:term":[{"taxonomy":"schedule","embeddable":true,"href":"https:\/\/cognitionconferences.com\/virology\/wp-json\/wp\/v2\/schedule?post=5223"},{"taxonomy":"speaker-category","embeddable":true,"href":"https:\/\/cognitionconferences.com\/virology\/wp-json\/wp\/v2\/speaker-category?post=5223"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}