{"id":5065,"date":"2026-01-12T08:26:22","date_gmt":"2026-01-12T08:26:22","guid":{"rendered":"https:\/\/cognitionconferences.com\/virology\/?post_type=speaker&#038;p=5065"},"modified":"2026-01-12T08:26:46","modified_gmt":"2026-01-12T08:26:46","slug":"5065","status":"publish","type":"speaker","link":"https:\/\/cognitionconferences.com\/virology\/speaker\/5065\/","title":{"rendered":"Wojciech Golusinski"},"content":{"rendered":"<p><strong><span style=\"font-size: 10.5pt; font-family: 'Arial',sans-serif; color: #333333;\">Abstract<\/span><\/strong><b><span style=\"font-size: 10.5pt; font-family: 'Arial',sans-serif; color: #333333;\"><br \/>\n<\/span><\/b><span style=\"font-size: 10.5pt; font-family: 'Arial',sans-serif; color: #333333;\"><br \/>\nHead and neck squamous-cell carcinoma (HNSCC) includes malignancies of the hypopharynx, nasopharynx, oral cavity, oropharynx, and larynx. Traditionally linked to tobacco and alcohol use, a growing subset\u2014particularly oropharyngeal squamous-cell carcinoma (OPSCC)\u2014is now associated with HPV infection.<\/span><\/p>\n<p><span style=\"font-size: 10.5pt; font-family: 'Arial',sans-serif; color: #333333;\">Over the past two decades, the incidence of HPV-positive OPSCC has risen significantly, especially in high-income regions such as North America and northern Europe, likely due to changes in sexual behavior. In many European countries, more than 50% of OPSCC cases are HPV-related. According to GLOBOCAN 2022, an estimated 29,800 new cases and 13,027 deaths from oropharyngeal cancer occurred in Europe in 2022.<\/span><\/p>\n<p><span style=\"font-size: 10.5pt; font-family: 'Arial',sans-serif; color: #333333;\">HPV-related OPSCC follows a distinct molecular pathway. Viral oncoproteins E6 and E7 inactivate tumour suppressor proteins (p53 and Rb), leading to uncontrolled cell proliferation and genomic instability. Additional pathways such as PI3K\/AKT\/mTOR, Notch, and Wnt\/\u03b2-catenin are also involved.<\/span><\/p>\n<p><span style=\"font-size: 10.5pt; font-family: 'Arial',sans-serif; color: #333333;\">Prognosis in HNSCC depends largely on tumour stage and HPV status. Patients with HPV-positive OPSCC generally have better outcomes, although discordance between p16 expression and HPV DNA status (e.g., p16\u2212\/HPV+ or p16+\/HPV\u2212) is linked to worse survival.<\/span><\/p>\n<p><span style=\"font-size: 10.5pt; font-family: 'Arial',sans-serif; color: #333333;\">Treatment typically involves a multimodal approach including surgery, radiation, and chemotherapy. Further research is needed to clarify HPV-related carcinogenesis, improve early detection, and personalize treatment. Increasing HPV vaccination coverage\u2014especially among boys\u2014along with better screening, could significantly reduce future cancer burden.<\/span><\/p>\n<p><span style=\"font-size: 10.5pt; font-family: 'Arial',sans-serif; color: #333333;\">This review summarizes the current status of HPV-driven HNSCC in Europe.<\/span><\/p>\n","protected":false},"featured_media":5044,"template":"","meta":{"_acf_changed":false},"schedule":[],"speaker-category":[],"class_list":["post-5065","speaker","type-speaker","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Wojciech Golusinski - Cognition Conferences<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cognitionconferences.com\/virology\/speaker\/5065\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Wojciech Golusinski - Cognition Conferences\" \/>\n<meta property=\"og:description\" content=\"Abstract Head and neck squamous-cell carcinoma (HNSCC) includes malignancies of the hypopharynx, nasopharynx, oral cavity, oropharynx, and larynx. Traditionally linked to tobacco and alcohol use, a growing subset\u2014particularly oropharyngeal squamous-cell carcinoma (OPSCC)\u2014is now associated with HPV infection. 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