{"id":5242,"date":"2026-07-20T11:35:31","date_gmt":"2026-07-20T11:35:31","guid":{"rendered":"https:\/\/cognitionconferences.com\/tissueengineering\/?post_type=speaker&p=5242"},"modified":"2026-07-20T11:46:18","modified_gmt":"2026-07-20T11:46:18","slug":"lihong-fan","status":"publish","type":"speaker","link":"https:\/\/cognitionconferences.com\/tissueengineering\/speaker\/lihong-fan\/","title":{"rendered":"Lihong Fan"},"content":{"rendered":"

Abstract<\/p>\n

Lihong Fan1,2, Yingjie Zhu3. drfan2140@xjtu.edu.cn, 1.Xi’an Jiaotong University; 2.Department of orthopedics, Sanya Central Hospital; 3.Luoyang Orthopedic-Traumatological Hospital
\nBackground: The repair of critical-sized bone defects remains a significant clinical challenge due to the limited availability of autografts and the functional limitations of current synthetic substitutes. While Gelatin Methacryloyl (GelMA) hydrogels offer excellent biocompatibility and injectability, their application is restricted by insufficient mechanical strength and rapid degradation. This study aims to develop a novel composite hydrogel that integrates mechanical reinforcement with controlled drug delivery to enhance bone regeneration.
\nMethods: We designed an injectable, photocrosslinkable composite hydrogel by incorporating Icariin (ICA)-loaded Mesoporous Silica Nanoparticles (MSNs) into a GelMA matrix. The physicochemical properties, including microstructure, rheology, and degradation, were characterized. The pH-responsive release profile of ICA was evaluated. In vitro, the effects of the hydrogel on rat bone marrow mesenchymal stem cell (rBMSC) proliferation and osteogenic differentiation were assessed via CCK-8, Live\/Dead staining, ALP\/ARS staining, and RT-qPCR. In vivo bone regeneration potential was evaluated using a rat calvarial defect model, analyzed via micro-CT and histological staining at 6 and 12 weeks.
\nResults: The incorporation of MSNs increased the compressive modulus of the hydrogel by approximately 1.5-fold (12.3 \u00b1 1.2 kPa) compared to pure GelMA. The composite system exhibited a sustained, pH-responsive release of ICA, with 91.2% cumulative release over 15 days. In vitro experiments demonstrated that the GelMA\/MSN\/ICA hydrogel significantly promoted rBMSC proliferation and upregulated osteogenic gene expression (ALP, Runx2, Col1). In vivo, micro-CT analysis revealed a significantly higher bone volume fraction (BV\/TV) in the composite group at 12 weeks. Histological examination confirmed the formation of mature trabecular bone and enhanced collagen deposition compared to control groups.
\nConclusion: The developed GelMA\/MSN\/ICA composite hydrogel effectively combines mechanical adaptability with the spatiotemporal delivery of osteogenic agents. This multifunctional system provides a favorable microenvironment for stem cell differentiation and significantly accelerates osseointegration, presenting a promising strategy for non-load-bearing bone tissue engineering applications.
\nKeywords: Bone Tissue Engineering, GelMA Hydrogel, Mesoporous Silica Nanoparticles, Icariin, Osseointegration.<\/p>\n","protected":false},"featured_media":5240,"template":"","meta":{"_acf_changed":false},"schedule":[],"speaker-category":[6],"class_list":["post-5242","speaker","type-speaker","status-publish","has-post-thumbnail","hentry","speaker-category-speakers"],"acf":[],"yoast_head":"\nLihong Fan| Xi'an Jiaotong University| China<\/title>\n<meta name=\"description\" content=\"Dr. Lihong Fan, MD, PhD, is a Professor, Senior Chief Physician (Grade II), and Doctoral Supervisor at Xi'an Jiaotong University, serving in the Department of Orthopaedics at The Second Affiliated Hospital, Xi'an, China. He also serves as Deputy Director of the Operation & Management Office. Recognized as a National-Level Clinical Scientist (Grade III), Dr. Fan has established an outstanding reputation in orthopaedic surgery, regenerative medicine, and translational research. His research focuses on minimally invasive arthroscopic surgery, tendon repair, osteonecrosis treatment, joint preservation, biomaterials, exosome-based therapies, and tissue engineering. He has developed several innovative arthroscopic surgical techniques and advanced biomaterial-based regenerative therapies, including miRNA-engineered exosomes and injectable hydrogel systems. As Principal Investigator, he has secured three National Natural Science Foundation of China (NSFC) grants and holds two Chinese invention patents. Dr. Fan has published more than 45 SCI-indexed research articles in leading journals, achieving an H-index of 24. He has successfully supervised numerous PhD and master's students and actively contributes to the scientific community as a reviewer for prestigious journals, including Bone, Acta Biomaterialia, Stem Cell Research & Therapy, and Arthroscopy Techniques. His work continues to advance innovative surgical techniques and regenerative therapies aimed at improving patient outcomes in orthopaedic medicine.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cognitionconferences.com\/tissueengineering\/speaker\/lihong-fan\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Lihong Fan| Xi'an Jiaotong University| China\" \/>\n<meta property=\"og:description\" content=\"Dr. Lihong Fan, MD, PhD, is a Professor, Senior Chief Physician (Grade II), and Doctoral Supervisor at Xi'an Jiaotong University, serving in the Department of Orthopaedics at The Second Affiliated Hospital, Xi'an, China. He also serves as Deputy Director of the Operation & Management Office. Recognized as a National-Level Clinical Scientist (Grade III), Dr. Fan has established an outstanding reputation in orthopaedic surgery, regenerative medicine, and translational research. His research focuses on minimally invasive arthroscopic surgery, tendon repair, osteonecrosis treatment, joint preservation, biomaterials, exosome-based therapies, and tissue engineering. He has developed several innovative arthroscopic surgical techniques and advanced biomaterial-based regenerative therapies, including miRNA-engineered exosomes and injectable hydrogel systems. As Principal Investigator, he has secured three National Natural Science Foundation of China (NSFC) grants and holds two Chinese invention patents. Dr. Fan has published more than 45 SCI-indexed research articles in leading journals, achieving an H-index of 24. He has successfully supervised numerous PhD and master's students and actively contributes to the scientific community as a reviewer for prestigious journals, including Bone, Acta Biomaterialia, Stem Cell Research & Therapy, and Arthroscopy Techniques. His work continues to advance innovative surgical techniques and regenerative therapies aimed at improving patient outcomes in orthopaedic medicine.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cognitionconferences.com\/tissueengineering\/speaker\/lihong-fan\/\" \/>\n<meta property=\"og:site_name\" content=\"Cognition Conferences\" \/>\n<meta property=\"article:modified_time\" content=\"2026-07-20T11:46:18+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/cognitionconferences.com\/tissueengineering\/wp-content\/uploads\/2026\/07\/Copy-of-Copy-of-Copy-of-Copy-of-Environemntal_Speaker_OCM-8.png\" \/>\n\t<meta property=\"og:image:width\" content=\"200\" \/>\n\t<meta property=\"og:image:height\" content=\"240\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/cognitionconferences.com\\\/tissueengineering\\\/speaker\\\/lihong-fan\\\/\",\"url\":\"https:\\\/\\\/cognitionconferences.com\\\/tissueengineering\\\/speaker\\\/lihong-fan\\\/\",\"name\":\"Lihong Fan| Xi'an Jiaotong University| China\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/cognitionconferences.com\\\/tissueengineering\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/cognitionconferences.com\\\/tissueengineering\\\/speaker\\\/lihong-fan\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/cognitionconferences.com\\\/tissueengineering\\\/speaker\\\/lihong-fan\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/cognitionconferences.com\\\/tissueengineering\\\/wp-content\\\/uploads\\\/2026\\\/07\\\/Copy-of-Copy-of-Copy-of-Copy-of-Environemntal_Speaker_OCM-8.png\",\"datePublished\":\"2026-07-20T11:35:31+00:00\",\"dateModified\":\"2026-07-20T11:46:18+00:00\",\"description\":\"Dr. Lihong Fan, MD, PhD, is a Professor, Senior Chief Physician (Grade II), and Doctoral Supervisor at Xi'an Jiaotong University, serving in the Department of Orthopaedics at The Second Affiliated Hospital, Xi'an, China. He also serves as Deputy Director of the Operation & Management Office. Recognized as a National-Level Clinical Scientist (Grade III), Dr. Fan has established an outstanding reputation in orthopaedic surgery, regenerative medicine, and translational research. His research focuses on minimally invasive arthroscopic surgery, tendon repair, osteonecrosis treatment, joint preservation, biomaterials, exosome-based therapies, and tissue engineering. He has developed several innovative arthroscopic surgical techniques and advanced biomaterial-based regenerative therapies, including miRNA-engineered exosomes and injectable hydrogel systems. As Principal Investigator, he has secured three National Natural Science Foundation of China (NSFC) grants and holds two Chinese invention patents. Dr. Fan has published more than 45 SCI-indexed research articles in leading journals, achieving an H-index of 24. He has successfully supervised numerous PhD and master's students and actively contributes to the scientific community as a reviewer for prestigious journals, including Bone, Acta Biomaterialia, Stem Cell Research & Therapy, and Arthroscopy Techniques. 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