{"id":5227,"date":"2026-06-30T12:37:47","date_gmt":"2026-06-30T12:37:47","guid":{"rendered":"https:\/\/cognitionconferences.com\/tissueengineering\/?post_type=speaker&#038;p=5227"},"modified":"2026-06-30T12:40:26","modified_gmt":"2026-06-30T12:40:26","slug":"chen-shunan","status":"publish","type":"speaker","link":"https:\/\/cognitionconferences.com\/tissueengineering\/speaker\/chen-shunan\/","title":{"rendered":"Chen Shunan"},"content":{"rendered":"<p><strong>Abstract<\/strong><\/p>\n<p>Orthodontic tooth movement (OTM) initiates sterile inflammation within the periodontal ligament, wherein macrophage polarization serves as a pivotal regulatory node of alveolar bone remodeling. Parathyroid hormone (PTH) possesses potent immunomodulatory and osteogenic properties; however, its impact on macrophage heterogeneity under mechanical stress remains incompletely understood. In this study, a co-culture system of human periodontal ligament cells (hPDLCs) and THP-1-derived macrophages was established and exposed to cyclic tensile stress, with or without PTH (1-34) treatment and pharmacological activation of the NLRP3 inflammasome using nigericin. Quantitative analyses revealed that mechanical loading induced early apoptosis in hPDLCs (3.2-fold increase vs. control, P&lt;0.001), elevated the M1 macrophage subset (CD68\u207aCD11b\u207a) by 2.7-fold (P&lt;0.001), and reduced M2 macrophages (CD68\u207aCD206\u207a) by 58% (P&lt;0.001). Concurrently, osteogenic markers BMP-2, OPG, and RUNX2 were markedly downregulated (P&lt;0.001), while pro-inflammatory mediators TNF-\u03b1, IL-1\u03b2, and iNOS were significantly upregulated (P&lt;0.001). PTH intervention reversed these alterations-restoring osteogenic protein expression to near-baseline levels (P&lt;0.001) and increasing anti-inflammatory IL-10 production (P&lt;0.001)-while shifting macrophage polarization toward the reparative M2 phenotype. These immunomodulatory effects were abolished by NLRP3 activation (P&lt;0.01). Importantly, these findings parallel clinical observations that PTH accelerates oral wound healing following tooth extraction or periodontal surgery by fostering a regenerative M2-dominant microenvironment and enhancing bone formation. In conclusion, PTH reprograms mechanical stress-induced M1 macrophages into an M2 reparative phenotype via inhibition of the NLRP3 inflammasome, thereby augmenting osteogenic transcription and curbing inflammatory bone resorption. Targeted modulation of the PTH-NLRP3 axis may constitute a translatable strategy to expedite OTM, mitigate adverse tissue reactions, and optimize clinical orthodontic protocols while minimizing iatrogenic complications.<\/p>\n","protected":false},"featured_media":5228,"template":"","meta":{"_acf_changed":false},"schedule":[],"speaker-category":[],"class_list":["post-5227","speaker","type-speaker","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Chen Shunan| Institute of Chemistry Chinese Academy of Sciences| China<\/title>\n<meta name=\"description\" content=\"Dr. Shunan Chen earned his Ph.D. in 2022 and subsequently joined the Institute of Chemistry, Chinese Academy of Sciences (ICCAS), where he conducts research at the intersection of nanotechnology and molecular biology. 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Committed to addressing unmet clinical needs, Dr. Chen has successfully led multiple translational medicine projects, effectively bridging fundamental neuroscience with clinical application.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cognitionconferences.com\/tissueengineering\/speaker\/chen-shunan\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Chen Shunan| Institute of Chemistry Chinese Academy of Sciences| China\" \/>\n<meta property=\"og:description\" content=\"Dr. Shunan Chen earned his Ph.D. in 2022 and subsequently joined the Institute of Chemistry, Chinese Academy of Sciences (ICCAS), where he conducts research at the intersection of nanotechnology and molecular biology. 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