Antimicrobial resistance is an escalating global health concern that severely compromises the management of recurrent infections. Recurrent urinary tract infections (UTIs) represent a particularly challenging condition in paediatric patients with structural urinary tract abnormalities and extensive prior antibiotic exposure, where infections are frequently caused by multiantibiotics-resistant and extended-spectrum \u03b2-lactamase (ESBL)-producing pathogens.<\/p>\n
To address this clinical need, a novel probiotic strain, Lactiplantibacillus<\/em> sp. LH01, was isolated and characterized from human milk and officially registered. Its clinical potential was evaluated in a pediatric patient with bilateral hydronephrosis, a history of repeated hospitalizations, and recurrent UTIs caused by ESBL-producing Escherichia coli<\/em> and Klebsiella pneumoniae<\/em>.<\/p>\n Administration of Lactiplantibacillus<\/em> ps. LH01 was associated with a marked reduction in UTI recurrence and a sustained clinical improvement. In vitro assays demonstrated an 89% inhibitory activity against ESBL-producing E. coli<\/em>. Notably, subsequent urinary cultures revealed loss of the ESBL phenotype and restoration of susceptibility to multiple antibiotics that had previously failed, suggesting a potential role in modulating antimicrobial resistance rather than solely suppressing bacterial growth. No adverse events or safety concerns were observed during treatment.<\/p>\n These findings support Lactiplantibacillus<\/em> sp. LH01 as an innovative and clinically relevant candidate for development as a Live Biotherapeutic Product. This probiotic-based approach may represent a novel adjunctive strategy to reduce antimicrobial resistance and improve outcomes in paediatric patients with recurrent UTIs, particularly in settings where therapeutic options are increasingly limited.<\/p>\n","protected":false},"featured_media":5138,"template":"","meta":{"_acf_changed":false},"schedule":[],"speaker-category":[],"class_list":["post-5136","speaker","type-speaker","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"\n