{"id":5033,"date":"2026-01-12T08:43:45","date_gmt":"2026-01-12T08:43:45","guid":{"rendered":"https:\/\/cognitionconferences.com\/obesity\/?post_type=speaker&#038;p=5033"},"modified":"2026-01-12T08:43:45","modified_gmt":"2026-01-12T08:43:45","slug":"hongying-cai","status":"publish","type":"speaker","link":"https:\/\/cognitionconferences.com\/obesity\/speaker\/hongying-cai\/","title":{"rendered":"Hongying Cai"},"content":{"rendered":"<p>Fatty liver hemorrhage syndrome (FLHS) is a major cause of death in caged laying hens, associated with oxidative stress, hepatocyte injury, and inflammation. This study investigated the protective mechanisms of\u00a0<em>Lactiplantibacillus plantarum\u00a0<\/em>FRT4, focusing on its antioxidant and anti-inflammatory functions. Dietary supplementation with\u00a0<em>Lp. plantarum<\/em>\u00a0FRT4 significantly enhanced hepatic and ovarian antioxidant capacity, elevating levels of T-AOC, T-SOD, and GSH-Px, while upregulating gene expression of\u00a0<em>SOD1<\/em>,<em>\u00a0SOD2<\/em>,\u00a0<em>CAT<\/em>, and\u00a0<em>GPX1<\/em>. Concurrently, it reduced pro inflammatory cytokines such as TNF-\u03b1, IL-1\u03b2, and NLRP3, and downregulated mRNA levels of\u00a0<em>IL-1\u03b2<\/em>,\u00a0<em>IL-6<\/em>, and\u00a0<em>NLRP3<\/em>, while promoting anti-inflammatory factors including IL-4 and IL-10. The intervention also remodeled gut microbiota composition, notably increasing beneficial genera like\u00a0<em>Prevotella<\/em>\u00a0and\u00a0<em>Alistipes<\/em>, and influenced metabolic pathways related to tryptophan metabolism and FoxO signaling. Spearman correlation analysis confirmed close associations between microbial shifts and improvements in antioxidant and inflammatory indicators. Further mechanistic studies revealed that\u00a0<em>Lp. plantarum<\/em>\u00a0FRT4 modulates the<em>\u00a0FoxO\/TLR-4\/NF-\u03baB<\/em>\u00a0signaling pathway through microbiota-mediated regulation, thereby mitigating oxidative damage and inflammatory responses. Ovarian function was likewise improved, as evidenced by increased levels of E2, FSH, and VTG. In summary,\u00a0<em>Lp. plantarum\u00a0<\/em>FRT4 alleviates FLHS by enhancing antioxidant defenses, suppressing inflammation, restructuring gut microbiota, and regulating the\u00a0<em>FoxO\/TLR-4\/NF-\u03baB<\/em>\u00a0pathway, collectively supporting liver and ovarian health. Notably, these mechanisms share parallels with human metabolic associated fatty liver disease (NAFLD), suggesting that targeting the gut liver axis with probiotics could offer a promising strategy for ameliorating metabolic and inflammatory liver conditions in humans, warranting further investigation<\/p>\n","protected":false},"featured_media":5009,"template":"","meta":{"_acf_changed":false},"schedule":[],"speaker-category":[6],"class_list":["post-5033","speaker","type-speaker","status-publish","has-post-thumbnail","hentry","speaker-category-speakers"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Hongying Cai - Cognition Conferences<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cognitionconferences.com\/obesity\/speaker\/hongying-cai\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Hongying Cai - Cognition Conferences\" \/>\n<meta property=\"og:description\" content=\"Fatty liver hemorrhage syndrome (FLHS) is a major cause of death in caged laying hens, associated with oxidative stress, hepatocyte injury, and inflammation. This study investigated the protective mechanisms of\u00a0Lactiplantibacillus plantarum\u00a0FRT4, focusing on its antioxidant and anti-inflammatory functions. Dietary supplementation with\u00a0Lp. plantarum\u00a0FRT4 significantly enhanced hepatic and ovarian antioxidant capacity, elevating levels of T-AOC, T-SOD, and [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cognitionconferences.com\/obesity\/speaker\/hongying-cai\/\" \/>\n<meta property=\"og:site_name\" content=\"Cognition Conferences\" \/>\n<meta property=\"og:image\" content=\"https:\/\/cognitionconferences.com\/obesity\/wp-content\/uploads\/2026\/01\/Hongying-Cai-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"271\" \/>\n\t<meta property=\"og:image:height\" content=\"388\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/cognitionconferences.com\/obesity\/speaker\/hongying-cai\/\",\"url\":\"https:\/\/cognitionconferences.com\/obesity\/speaker\/hongying-cai\/\",\"name\":\"Hongying Cai - Cognition Conferences\",\"isPartOf\":{\"@id\":\"https:\/\/cognitionconferences.com\/obesity\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/cognitionconferences.com\/obesity\/speaker\/hongying-cai\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/cognitionconferences.com\/obesity\/speaker\/hongying-cai\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/cognitionconferences.com\/obesity\/wp-content\/uploads\/2026\/01\/Hongying-Cai-1.jpg\",\"datePublished\":\"2026-01-12T08:43:45+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/cognitionconferences.com\/obesity\/speaker\/hongying-cai\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/cognitionconferences.com\/obesity\/speaker\/hongying-cai\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/cognitionconferences.com\/obesity\/speaker\/hongying-cai\/#primaryimage\",\"url\":\"https:\/\/cognitionconferences.com\/obesity\/wp-content\/uploads\/2026\/01\/Hongying-Cai-1.jpg\",\"contentUrl\":\"https:\/\/cognitionconferences.com\/obesity\/wp-content\/uploads\/2026\/01\/Hongying-Cai-1.jpg\",\"width\":271,\"height\":388},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/cognitionconferences.com\/obesity\/speaker\/hongying-cai\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/cognitionconferences.com\/obesity\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Hongying Cai\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/cognitionconferences.com\/obesity\/#website\",\"url\":\"https:\/\/cognitionconferences.com\/obesity\/\",\"name\":\"Cognition Conferences\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/cognitionconferences.com\/obesity\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Hongying Cai - Cognition Conferences","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/cognitionconferences.com\/obesity\/speaker\/hongying-cai\/","og_locale":"en_US","og_type":"article","og_title":"Hongying Cai - Cognition Conferences","og_description":"Fatty liver hemorrhage syndrome (FLHS) is a major cause of death in caged laying hens, associated with oxidative stress, hepatocyte injury, and inflammation. 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