{"id":5089,"date":"2026-09-25T05:51:23","date_gmt":"2026-09-25T05:51:23","guid":{"rendered":"https:\/\/cognitionconferences.com\/infectiousdisease\/?post_type=speaker&p=5089"},"modified":"2026-09-25T05:51:23","modified_gmt":"2026-09-25T05:51:23","slug":"amani-saud-alhejely","status":"publish","type":"speaker","link":"https:\/\/cognitionconferences.com\/infectiousdisease\/speaker\/amani-saud-alhejely\/","title":{"rendered":"Amani Saud Alhejely"},"content":{"rendered":"

Abstract:
\n<\/strong>
\nTrichomonas vaginalis is the causative agent of trichomoniasis, one of the most common non-viral sexually transmitted infections worldwide. Treatment options remain limited, and increasing resistance to metronidazole, the current first-line therapy, represents a growing public health concern, while the discovery of new therapeutic candidates has been hindered by limitations in efficient and reliable drug-screening approaches. In this study, an optimized resorufin-based drug screening assay was developed to facilitate the identification and evaluation of compounds with activity against T. vaginalis. The assay incorporates a cell-based plate-reader system, a multidrop dispenser, airtight incubation pods to maintain stable microaerobic conditions, and a fluorescencebased readout of parasite metabolic activity. The method exploits the reductive capacity of T. vaginalis to sequentially reduce resazurin to resorufin and subsequently to dihydroresorufin, producing a measurable fluorescence signal proportional to parasite cell numbers. Several compound series were evaluated using the optimized assay. A series of 7-substituted 7- deazaadenosine analogues demonstrated potent activity against T. vaginalis, with EC50 measurements showing superior inhibitory activity compared with metronidazole, while toxicity toward mammalian cell lines remained low. Subsequent synthesis and structure\u2013activity relationship analysis identified an optimized pharmacophore within this scaffold, and several 7- deazaadenosine analogues rapidly cleared T. vaginalis cultures at concentrations as low as 2\u00d7EC50. These findings demonstrate the potential of the optimized resorufin-based assay as an effective platform for anti-Trichomonas drug screening and highlight 7-deazaadenosine analogues as promising candidates for the development of new therapeutic strategies for trichomoniasis.<\/p>\n

Biography:\u00a0<\/strong><\/p>\n

Dr. Amani Alhejely is an Assistant Professor of Immunology, Molecular Parasitology and Microbiology at Jazan University, Saudi Arabia. She obtained her PhD in Infection, Immunity and Inflammation from the University of Glasgow, United Kingdom, and her MSc in Microbiology and Immunology from Wright State University, USA. Her research focuses on antimicrobial drug discovery, molecular diagnostics and infectious diseases, with particular emphasis on highthroughput drug screening against Trichomonas vaginalis. She is the inventor of several Saudi patent applications in drug discovery and immunotherapy, a recipient of national and international innovation awards, and currently serves as Head of the Research and Innovation Unit.<\/p>\n","protected":false},"featured_media":5087,"template":"","meta":{"_acf_changed":false},"schedule":[5],"speaker-category":[6],"class_list":["post-5089","speaker","type-speaker","status-publish","has-post-thumbnail","hentry","schedule-day-1","speaker-category-speakers"],"acf":[],"yoast_head":"\nAmani Saud Alhejely | Jazan University | Saudi Arabia<\/title>\n<meta name=\"description\" content=\"Dr. Amani Alhejely is an Assistant Professor of Immunology, Molecular Parasitology and Microbiology at Jazan University, Saudi Arabia. She obtained her PhD in Infection, Immunity and Inflammation from the University of Glasgow, United Kingdom, and her MSc in Microbiology and Immunology from Wright State University, USA. Her research focuses on antimicrobial drug discovery, molecular diagnostics and infectious diseases, with particular emphasis on highthroughput drug screening against Trichomonas vaginalis. 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