Background: Periodontitis is a biofilm-associated inflammatory disease characterized by dysbiosis
\nof the oral microbial community and increased pathogenic bacteria, including Porphyromonas
\ngingivalis, Fusobacterium nucleatum, and Aggregatibacter actinomycetemcomitans. The increasing
\nconcern regarding antimicrobial resistance has encouraged investigation of natural antimicrobial
\nagents. Manuka honey contains methylglyoxal (MGO), which has demonstrated antimicrobial
\nactivity against important periodontal pathogens in previous in-vitro studies.
\nObjectives: To evaluate the clinical effectiveness of adjunctive Manuka honey oral rinse following
\nnonsurgical periodontal therapy (NSPT) in hemodialysis patients with Stage III periodontitis and to
\ninvestigate changes in periodontal parameters and inflammatory biomarkers.
\nMethods: A randomized, blinded, controlled clinical trial included 140 hemodialysis patients with
\nStage III periodontitis. Participants received NSPT followed by either Manuka honey oral rinse
\n(n=70) or saline rinse (n=70) for 6 months. Clinical attachment level (CAL), probing depth (PD),
\nbleeding on probing (BOP), plaque index, gingival crevicular fluid FGF23, serum C-reactive
\nprotein (CRP), and oral health-related quality of life were assessed.
\nResults: At 6 months, the Manuka honey group demonstrated significantly greater improvements in
\nCAL, PD, and BOP compared with controls. Significant reductions in GCF FGF23 and serum CRP
\nwere also observed, together with improved oral health-related quality of life.
\nConclusion: Adjunctive Manuka honey oral rinse produced additional clinical and inflammatory
\nimprovements following NSPT in hemodialysis patients with periodontitis. Its potential
\nantimicrobial activity against periodontal pathogens supports further microbiological investigation
\nof Manuka honey as a non-antibiotic adjunctive approach to periodontal infection management.<\/p>\n","protected":false},"featured_media":5337,"menu_order":15,"template":"","meta":{"_acf_changed":false},"schedule":[7],"speaker-category":[6],"class_list":["post-5336","speaker","type-speaker","status-publish","has-post-thumbnail","hentry","schedule-day-2","speaker-category-speakers"],"acf":[],"yoast_head":"\n