Fish-borne parasitic zoonoses  are common neglected tropical diseases in Southeast Asia such as Thailand, Lao People’s Democratic Republic (Lao PDR), Vietnam, Cambodia, and Myanmar. At present, there is still a lack of evidence based as current situation of these Fish-borne parasitic zoonoses to national control program, the real situation to know the rate of infections among people who have lived in the border line along the Mekong region where the disease is spreading and continuing transmission of all neglected tropical diseases.  Currently, multiple data suggest that pathogenic trematode metacercariae are present in freshwater fish, most notably small liver flukes (Opisthorchis viverrini). Opisthorchiasis is also Thailand’s most serious public health disease, having been identified as one of the most serious parasitic zoonoses, with national control programs in place. The epicenter of the disease in Thailand is in the northeast, where a high prevalence of opisthorchiasis coexists with a high incidence of cholangiocarcinoma (CCA), a significant primary liver carcinoma with a poor prognosis. Fish-borne trematode metacercariae, which are related to carcinogenic liver fluke and minute intestinal flukes, are found in a range of cyprinoid fish species. Additionally, phenomenal could provide evidence that leads to improved public health awareness for surveillance  and control, as well as contribute to filling the information gap needed for the control and prevention of fish-borne parasitic zoonoses in Mekong region countries. Many important factors influence the transmission rates of infection in the prevention and control programs dealing with parasitic progress. In the case of opisthorchiasis, disease is transmitted mostly through raw or undercooked fish consumption. The trends and risk factors that correspond with infections among rural Thai people would be the focus of the geographic information system study. The national campaign program has already demonstrated the impact of a national program that is beneficial to all countries, particularly those in the Mekong basin, in terms of opisthorchiasis elimination and control. The 10-year strategic plan for the elimination of the liver fluke and CCA indicated that the overall prevalence of opisthorchiasis was declining, demonstrating the critical support from strategy and policy makers. This health informatics model can therefore be used to build tools and programs for the prediction, prevention, and control of fish-borne parasite zoonoses, potentially resulting in a reduction in the prevalence of illness, particularly in distant places.